Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL750216

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of outward potassium currents (IKn) in human T-lymphocyte N-type potassium channels.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Potassium voltage-gated channel subfamily A member 3 (CHEMBL4633)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel inhibitors of potassium ion channels on human T lymphocytes.
Michne WF, Guiles JW, Treasurywala AM, Castonguay LA, Weigelt CA, Oconnor B, Volberg WA, Grant AM, Chadwick CC, Krafte DS.
J Med Chem (1995) 38 : 1877 -1883
PubMed 7540207 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.34 6.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL416313 1 6.67
CHEMBL298622 1 6.67
CHEMBL53676 1 6.64
CHEMBL54934 1 6.60
CHEMBL299668 1 6.60
CHEMBL54846 1 6.59
CHEMBL293721 1 6.57
CHEMBL56590 1 6.55
CHEMBL55202 1 6.48
CHEMBL53841 1 6.47
CHEMBL298608 1 6.46
CHEMBL56589 1 6.36
CHEMBL59308 1 6.22
CHEMBL56173 1 5.98
CHEMBL56261 1 5.78
CHEMBL293083 1 5.58
CHEMBL55791 1 5.50
CHEMBL59482 1 -
CHEMBL293719 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL416313 IC50 = 213.0 nM 6.67
CHEMBL298622 IC50 = 216.0 nM 6.67
CHEMBL53676 IC50 = 231.0 nM 6.64
CHEMBL54934 IC50 = 249.0 nM 6.60
CHEMBL299668 IC50 = 250.0 nM 6.60
CHEMBL54846 IC50 = 259.0 nM 6.59
CHEMBL293721 IC50 = 267.0 nM 6.57
CHEMBL56590 IC50 = 279.0 nM 6.55
CHEMBL55202 IC50 = 329.0 nM 6.48
CHEMBL53841 IC50 = 335.0 nM 6.47
CHEMBL298608 IC50 = 351.0 nM 6.46
CHEMBL56589 IC50 = 434.0 nM 6.36
CHEMBL59308 IC50 = 602.0 nM 6.22
CHEMBL56173 IC50 = 1053.0 nM 5.98
CHEMBL56261 IC50 = 1676.0 nM 5.78
CHEMBL293083 IC50 = 2620.0 nM 5.58
CHEMBL55791 IC50 = 3160.0 nM 5.50
CHEMBL59482 IC50 > 10000.0 nM -
CHEMBL293719 IC50 > 10000.0 nM -