Compound Detail
CHEMBL55202
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Basic Information
| ChEMBL ID | CHEMBL55202 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VDAFVZGWQWRKRX-YYDJUVGSSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
382.9
MW (Da)
5.83
ALogP
3
HBA
0
HBD
26.5
PSA (Ų)
0.45
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 3 CHEMBL4633 | IC50 | 7.06 | 6.77 | 88.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 3 | IC50 | = | 88.0 | nM | 7.06 | Concentration inhibiting [125I]ChTX (charybdotoxin) binding to N-type potassium ... | 7540207 |
| Potassium voltage-gated channel subfamily A member 3 | IC50 | = | 329.0 | nM | 6.48 | Inhibition of outward potassium currents (IKn) in human T-lymphocyte N-type pota... | 7540207 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7540207 | 10.1021/jm00011a007 | Potassium voltage-gated channel subfamily A member 3 | 2 |
Data from ChEMBL 36 via Core Engine