Assay Detail
Binding
CHEMBL750405
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Binding affinity against NR1A/2B receptor in rat brains by [3H]ifenprodil displacement.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; Grin1/Grin2b (CHEMBL2096666) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Subtype selective NMDA receptor antagonists: evaluation of some novel alkynyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.51 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19849 | — | — | 1 | 8.70 |
| CHEMBL19506 | — | — | 1 | 8.52 |
| CHEMBL19419 | — | — | 1 | 8.40 |
| CHEMBL19404 | — | — | 1 | 8.05 |
| CHEMBL19636 | — | — | 1 | 7.85 |
| CHEMBL283753 | — | — | 1 | 7.82 |
| CHEMBL19559 | — | — | 1 | 7.72 |
| CHEMBL19349 | — | — | 1 | 7.70 |
| CHEMBL19576 | — | — | 1 | 7.68 |
| CHEMBL19342 | — | — | 1 | 7.62 |
| CHEMBL280882 | — | — | 1 | 7.51 |
| CHEMBL19952 | — | — | 1 | 7.29 |
| CHEMBL19957 | — | — | 1 | 7.25 |
| CHEMBL417822 | — | — | 1 | 7.00 |
| CHEMBL416000 | — | — | 1 | 6.98 |
| CHEMBL19590 | — | — | 1 | 6.85 |
| CHEMBL19769 | — | — | 1 | 6.80 |
| CHEMBL280200 | — | — | 1 | 6.55 |
| CHEMBL19945 | — | — | 1 | 6.32 |
| CHEMBL19929 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19849 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL19506 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL19419 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL19404 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL19636 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL283753 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL19559 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL19349 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL19576 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL19342 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL280882 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL19952 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL19957 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL417822 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL416000 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL19590 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL19769 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL280200 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL19945 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL19929 | — | IC50 | > | 1000.0 | nM | - |