Compound Detail
CHEMBL280200
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL280200 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DNMQIWRAJSXHTF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
363.4
MW (Da)
3.71
ALogP
3
HBA
2
HBD
52.1
PSA (Ų)
0.70
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor; Grin1/Grin2b CHEMBL2096666 | IC50 | 6.55 | 6.55 | 284.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor; Grin1/Grin2b | IC50 | = | 284.0 | nM | 6.55 | Binding affinity against NR1A/2B receptor in rat brains by [3H]ifenprodil displa... | 14980668 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14980668 | 10.1016/j.bmcl.2003.12.049 | Rattus norvegicus | 2 |
| 14980668 | 10.1016/j.bmcl.2003.12.049 | Glutamate NMDA receptor; Grin1/Grin2b | 1 |
Data from ChEMBL 36 via Core Engine