Assay Detail
Functional
CHEMBL750685
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In vitro inhibition of NIH3T3 cell proliferation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
4-methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.33 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 8.77 |
| CHEMBL343172 | — | — | 1 | 7.92 |
| CHEMBL136831 | — | — | 1 | 7.62 |
| CHEMBL137087 | — | — | 1 | 7.24 |
| CHEMBL342827 | — | — | 1 | 7.10 |
| CHEMBL344642 | — | — | 1 | 6.82 |
| CHEMBL342254 | — | — | 1 | 6.76 |
| CHEMBL344703 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL343172 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL136831 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL137087 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL342827 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL344642 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL342254 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL344703 | — | IC50 | = | 400.0 | nM | 6.40 |