Compound Detail
CHEMBL344703
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL344703 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YLWZTUJNSOKAOC-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
476.4
MW (Da)
5.93
ALogP
5
HBA
2
HBD
71.2
PSA (Ų)
0.34
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| NIH3T3 CHEMBL614822 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 4.0 | nM | 8.4 | Inhibition of [3H]FPP incorporation into biotinylated lamin B peptide by farnesy... | 14643326 |
| NIH3T3 | IC50 | = | 400.0 | nM | 6.4 | In vitro inhibition of NIH3T3 cell proliferation | 14643326 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14643326 | 10.1016/j.bmcl.2003.09.043 | Protein farnesyltransferase | 1 |
| 14643326 | 10.1016/j.bmcl.2003.09.043 | NIH3T3 | 1 |
Data from ChEMBL 36 via Core Engine