Assay Detail
Binding
CHEMBL751116
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Opioid receptor delta 1 by displacement of radioligand [3H]DSLET in rat brain membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely high mu opioid receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.40 | 6.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2371281 | — | — | 1 | 6.78 |
| CHEMBL2371286 | — | — | 1 | 6.74 |
| CHEMBL317264 | — | — | 1 | 6.20 |
| CHEMBL38874 | DAMGO | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2371281 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL2371286 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL317264 | — | Ki | = | 626.0 | nM | 6.20 |
| CHEMBL38874 | DAMGO | Ki | = | 1280.0 | nM | 5.89 |