Assay Detail
Binding
CHEMBL751139
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for the binding of [3H]dizocilpine to NMDA receptor in rat brain membranes in the presence of 500 uM spermidine
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Interaction of rigid polyamine analogues with the NMDA receptor complex from rat brain
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.38 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355194 | — | — | 1 | 5.66 |
| CHEMBL355307 | PHENOSAFRANINE | — | 1 | 5.36 |
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 5.13 |
| CHEMBL345124 | PROPIDIUM | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355194 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL355307 | PHENOSAFRANINE | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 7340.0 | nM | 5.13 |
| CHEMBL345124 | PROPIDIUM | IC50 | > | 1000000.0 | nM | - |