Assay Detail
Binding
CHEMBL751157
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In vitro binding affinity in LLC-PK1 cells by Norepinephrine transporter binding assay by using [125I]-IPT as a radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | LLC-PK1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.66 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142158 | — | — | 1 | 6.19 |
| CHEMBL23034 | — | — | 1 | 6.08 |
| CHEMBL142517 | — | — | 1 | 5.55 |
| CHEMBL356755 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142158 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL23034 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL142517 | — | Ki | = | 2810.0 | nM | 5.55 |
| CHEMBL356755 | — | Ki | = | 15050.0 | nM | 4.82 |