Assay Detail
Binding
CHEMBL751164
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Inhibition of [3H]- nisoxatine binding to Norepinephrine transporter
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.04 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159184 | — | — | 1 | 6.41 |
| CHEMBL440191 | — | — | 1 | 6.33 |
| CHEMBL160812 | — | — | 1 | 6.17 |
| CHEMBL158427 | — | — | 1 | 6.15 |
| CHEMBL348100 | — | — | 1 | 6.12 |
| CHEMBL157757 | — | — | 1 | 6.08 |
| CHEMBL158832 | — | — | 1 | 5.97 |
| CHEMBL36074 | — | — | 1 | 5.94 |
| CHEMBL160897 | — | — | 1 | 5.93 |
| CHEMBL160559 | — | — | 1 | 5.83 |
| CHEMBL160488 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159184 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL440191 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL160812 | — | IC50 | = | 678.0 | nM | 6.17 |
| CHEMBL158427 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL348100 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL157757 | — | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL158832 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL36074 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL160897 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL160559 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL160488 | — | IC50 | = | 3340.0 | nM | 5.48 |