Compound Detail
CHEMBL348100
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Basic Information
| ChEMBL ID | CHEMBL348100 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HZGOKNSMFFIPIF-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
409.6
MW (Da)
6.08
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.42
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium-dependent dopamine transporter CHEMBL338 | IC50 | 8.39 | 8.39 | 4.1 | 1 |
| Rattus norvegicus CHEMBL376 | IC50 | 8.32 | 8.32 | 4.8 | 1 |
| Norepinephrine transporter CHEMBL304 | IC50 | 6.12 | 6.12 | 760.0 | 1 |
| Sodium-dependent serotonin transporter CHEMBL313 | IC50 | 5.98 | 5.98 | 1040.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium-dependent dopamine transporter | IC50 | = | 4.1 | nM | 8.39 | Inhibition of 3[H] WIN-35 428 binding to Dopamine transporter (DAT) | 11806716 |
| Rattus norvegicus | IC50 | = | 4.81 | nM | 8.32 | Concentration causing 50% Inhibition of [3H]- DA (Dopamine) uptake in rat striat... | 11806716 |
| Norepinephrine transporter | IC50 | = | 760.0 | nM | 6.12 | Inhibition of [3H]- nisoxatine binding to Norepinephrine transporter | 11806716 |
| Sodium-dependent serotonin transporter | IC50 | = | 1040.0 | nM | 5.98 | Inhibition of [3H]- citalopram binding to Serotonin transporter | 11806716 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11806716 | 10.1021/jm010316x | Sodium-dependent dopamine transporter | 1 |
| 11806716 | 10.1021/jm010316x | Sodium-dependent serotonin transporter | 1 |
| 11806716 | 10.1021/jm010316x | Norepinephrine transporter | 1 |
| 11806716 | 10.1021/jm010316x | Rattus norvegicus | 1 |
| 11806716 | 10.1021/jm010316x | Monoamine transporters; serotonin & dopamine | 1 |
| 11806716 | 10.1021/jm010316x | Monoamine transporters; Norepininephrine & dopamine | 1 |
| 11806716 | 10.1021/jm010316x | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine