Assay Detail
Binding
CHEMBL800740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]- citalopram binding to Serotonin transporter
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.80 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159184 | — | — | 1 | 6.07 |
| CHEMBL423061 | — | — | 1 | 6.03 |
| CHEMBL160812 | — | — | 1 | 6.01 |
| CHEMBL157757 | — | — | 1 | 5.99 |
| CHEMBL348100 | — | — | 1 | 5.98 |
| CHEMBL440191 | — | — | 1 | 5.97 |
| CHEMBL158427 | — | — | 1 | 5.83 |
| CHEMBL158832 | — | — | 1 | 5.81 |
| CHEMBL159128 | — | — | 1 | 5.81 |
| CHEMBL160897 | — | — | 1 | 5.62 |
| CHEMBL36074 | — | — | 1 | 5.54 |
| CHEMBL160559 | — | — | 1 | 5.38 |
| CHEMBL160488 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159184 | — | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL423061 | — | IC50 | = | 924.0 | nM | 6.03 |
| CHEMBL160812 | — | IC50 | = | 984.0 | nM | 6.01 |
| CHEMBL157757 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL348100 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL440191 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL158427 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL158832 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL159128 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL160897 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL36074 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL160559 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL160488 | — | IC50 | = | 4330.0 | nM | 5.36 |