Assay Detail
Functional
CHEMBL751312
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Ha-Ras processing in NIH3T3 Ras transformed cells.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Potent and selective non-cysteine-containing inhibitors of protein farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.38 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132645 | — | — | 1 | 6.52 |
| CHEMBL274122 | — | — | 1 | 6.46 |
| CHEMBL134726 | — | — | 1 | 6.40 |
| CHEMBL336327 | — | — | 1 | 5.30 |
| CHEMBL135544 | — | — | 1 | 5.00 |
| CHEMBL335064 | — | — | 1 | 5.00 |
| CHEMBL132588 | — | — | 1 | 5.00 |
| CHEMBL343987 | — | — | 1 | 4.40 |
| CHEMBL555621 | — | — | 1 | 4.30 |
| CHEMBL134396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132645 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL274122 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL134726 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL336327 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL135544 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL335064 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL132588 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL343987 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL555621 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL134396 | — | EC50 | < | 100.0 | nM | - |