Compound Detail
CHEMBL134726
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Basic Information
| ChEMBL ID | CHEMBL134726 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QRPJKDFOVPEXGU-QFIPXVFZSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
471.0
MW (Da)
4.92
ALogP
5
HBA
2
HBD
88.5
PSA (Ų)
0.44
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.4
IC50 1 meas. best 9.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2095178 | IC50 | 9.21 | 9.21 | 0.6 | 1 |
| NIH3T3 CHEMBL614822 | EC50 | 6.4 | 6.4 | 400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 0.61 | nM | 9.21 | In vitro inhibition of farnesyltransferase from bovine brain | 9784104 |
| NIH3T3 | EC50 | = | 400.0 | nM | 6.4 | Inhibition of Ha-Ras processing in NIH3T3 Ras transformed cells. | 9784104 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9784104 | 10.1021/jm980298s | Protein farnesyltransferase | 1 |
| 9784104 | 10.1021/jm980298s | NIH3T3 | 1 |
Data from ChEMBL 36 via Core Engine