Assay Detail
Binding
CHEMBL751458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-MK-801 binding to EAA receptor sites in rat cortical membranes
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.32 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280585 | — | — | 1 | 6.35 |
| CHEMBL420125 | — | — | 1 | 5.30 |
| CHEMBL112755 | — | — | 1 | 4.30 |
| CHEMBL276815 | (S)-AMPA | — | 1 | - |
| CHEMBL111651 | — | — | 1 | - |
| CHEMBL112402 | — | — | 1 | - |
| CHEMBL323742 | — | — | 1 | - |
| CHEMBL325096 | — | — | 1 | - |
| CHEMBL113180 | — | — | 1 | - |
| CHEMBL323052 | — | — | 1 | - |
| CHEMBL418837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280585 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL420125 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL112755 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL276815 | (S)-AMPA | EC50 | > | 100000.0 | nM | - |
| CHEMBL111651 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL112402 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL323742 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL325096 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL113180 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL323052 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL418837 | — | EC50 | > | 100000.0 | nM | - |