Assay Detail
Binding
CHEMBL751574
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Binding affinity against Opioid receptor mu 1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.74 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331883 | — | — | 1 | 10.89 |
| CHEMBL12391 | — | — | 1 | 10.70 |
| CHEMBL290429 | CARFENTANIL | 2.0 | 1 | 10.62 |
| CHEMBL121403 | — | — | 1 | 10.22 |
| CHEMBL609147 | — | — | 1 | 10.05 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 8.40 |
| CHEMBL435380 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331883 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL12391 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL290429 | CARFENTANIL | Ki | = | 0.024 | nM | 10.62 |
| CHEMBL121403 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL609147 | — | Ki | = | 0.089 | nM | 10.05 |
| CHEMBL596 | FENTANYL | Ki | = | 3.97 | nM | 8.40 |
| CHEMBL435380 | — | Ki | = | 47.7 | nM | 7.32 |