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Assay Detail

CHEMBL751666

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Ability to inhibit [3H]DADLE binding to rat brain delta receptor
26
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL269)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

(E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype.
Bertha CM, Vilner BJ, Mattson MV, Bowen WD, Becketts K, Xu H, Rothman RB, Flippen-Anderson JL, Rice KC.
J Med Chem (1995) 38 : 4776 -4785
PubMed 7490727 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 26 6.65 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL143800 3 8.15
CHEMBL38791 2 6.91
CHEMBL356639 1 6.85
CHEMBL145780 1 6.85
CHEMBL145296 3 6.76
CHEMBL146659 3 6.66
CHEMBL322468 3 6.62
CHEMBL145422 1 6.49
CHEMBL141381 3 6.47
CHEMBL110319 3 6.13
CHEMBL109124 2 -
CHEMBL358527 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL143800 Ki = 7.1 nM 8.15
CHEMBL38791 Ki = 122.0 nM 6.91
CHEMBL143800 Ki = 127.0 nM 6.90
CHEMBL145780 Ki = 142.0 nM 6.85
CHEMBL356639 Ki = 141.0 nM 6.85
CHEMBL145296 Ki = 175.0 nM 6.76
CHEMBL146659 Ki = 217.0 nM 6.66
CHEMBL146659 Ki = 222.0 nM 6.65
CHEMBL322468 Ki = 240.0 nM 6.62
CHEMBL322468 Ki = 271.0 nM 6.57
CHEMBL145422 Ki = 321.0 nM 6.49
CHEMBL141381 Ki = 336.0 nM 6.47
CHEMBL146659 Ki = 386.0 nM 6.41
CHEMBL38791 Ki = 505.0 nM 6.30
CHEMBL110319 Ki = 735.0 nM 6.13
CHEMBL110319 Ki = 1989.0 nM 5.70
CHEMBL145296 Ki > 400.0 nM -
CHEMBL143800 Ki > 500.0 nM -
CHEMBL322468 Ki > 500.0 nM -
CHEMBL141381 Ki > 1000.0 nM -
CHEMBL358527 Ki > 1000.0 nM -
CHEMBL110319 Ki > 500.0 nM -
CHEMBL109124 Ki > 500.0 nM -
CHEMBL109124 Ki > 500.0 nM -
CHEMBL145296 Ki > 400.0 nM -
CHEMBL141381 Ki > 500.0 nM -