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Assay Detail

CHEMBL751667

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]DSLET binding to delta 1 opioid receptors in rat brain membranes
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Brain
Subcellular Brain membranes
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL269)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides.
Gacel G, Zajac JM, Delay-Goyet P, Daugé V, Roques BP.
J Med Chem (1988) 31 : 374 -383
PubMed 2828622 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 23 7.27 8.87

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL127378 1 8.87
CHEMBL2370601 1 8.66
CHEMBL127711 1 8.58
CHEMBL125564 1 8.38
CHEMBL124283 1 8.32
CHEMBL125060 1 8.25
CHEMBL339020 1 8.14
CHEMBL2370602 1 8.12
CHEMBL340032 DADLE 1 8.11
CHEMBL338307 1 8.04
CHEMBL31421 1 7.96
CHEMBL338661 1 7.52
CHEMBL341480 1 7.51
CHEMBL2370600 1 7.41
CHEMBL70 MORPHINE 4.0 1 6.55
CHEMBL333064 1 6.40
CHEMBL419414 1 6.32
CHEMBL338773 1 6.22
CHEMBL275050 1 5.99
CHEMBL2370599 1 5.86
CHEMBL123631 1 5.46
CHEMBL341500 1 5.42
CHEMBL339002 1 5.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL127378 Ki = 1.35 nM 8.87
CHEMBL2370601 Ki = 2.2 nM 8.66
CHEMBL127711 Ki = 2.65 nM 8.58
CHEMBL125564 Ki = 4.18 nM 8.38
CHEMBL124283 Ki = 4.8 nM 8.32
CHEMBL125060 Ki = 5.6 nM 8.25
CHEMBL339020 Ki = 7.3 nM 8.14
CHEMBL2370602 Ki = 7.6 nM 8.12
CHEMBL340032 DADLE Ki = 7.7 nM 8.11
CHEMBL338307 Ki = 9.12 nM 8.04
CHEMBL31421 Ki = 10.9 nM 7.96
CHEMBL338661 Ki = 30.0 nM 7.52
CHEMBL341480 Ki = 30.7 nM 7.51
CHEMBL2370600 Ki = 39.0 nM 7.41
CHEMBL70 MORPHINE Ki = 280.0 nM 6.55
CHEMBL333064 Ki = 395.0 nM 6.40
CHEMBL419414 Ki = 480.0 nM 6.32
CHEMBL338773 Ki = 600.0 nM 6.22
CHEMBL275050 Ki = 1020.0 nM 5.99
CHEMBL2370599 Ki = 1370.0 nM 5.86
CHEMBL123631 Ki = 3450.0 nM 5.46
CHEMBL341500 Ki = 3810.0 nM 5.42
CHEMBL339002 Ki = 6880.0 nM 5.16