Assay Detail
Binding
CHEMBL751997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of purified mouse inducible nitric oxide synthase catalyzed [14C]L-citrulline production at a compound concentration of 1 mM in presence of 50 uM L-arginine
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.40 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540 | IMIDAZOLE | — | 1 | 4.40 |
| CHEMBL101317 | — | — | 1 | - |
| CHEMBL14189 | 2-PHENYLIMIDAZOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540 | IMIDAZOLE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL101317 | — | IC50 | = | 138000.0 | nM | - |
| CHEMBL14189 | 2-PHENYLIMIDAZOLE | IC50 | > | 1000000.0 | nM | - |