Assay Detail
Binding
CHEMBL752165
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Binding affinity against Muscarinic acetylcholine receptor using [3H]-OXO-M as the radioligand.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.55 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92421 | — | — | 1 | 9.70 |
| CHEMBL334387 | — | — | 1 | 9.40 |
| CHEMBL335503 | — | — | 1 | 9.10 |
| CHEMBL134860 | — | — | 1 | 8.70 |
| CHEMBL337509 | — | — | 1 | 8.70 |
| CHEMBL134937 | — | — | 1 | 8.43 |
| CHEMBL335496 | — | — | 1 | 8.40 |
| CHEMBL40121 | — | — | 1 | 8.17 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 8.05 |
| CHEMBL134830 | — | — | 1 | 7.85 |
| CHEMBL448736 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92421 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL334387 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL335503 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL134860 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL337509 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL134937 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL335496 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL40121 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL14 | CARBACHOL | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL134830 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL448736 | — | Ki | = | 30.0 | nM | 7.52 |