Assay Detail
Binding
CHEMBL752307
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]QNB binding to muscarinic acetylcholine receptor of rat heart membrane preparation.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Heart |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and muscarinic receptor activity of ester derivatives of 2-substituted 2-azabicyclo[2.2.1]heptan-5-ol and -6-ol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.73 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.47 |
| CHEMBL71589 | PILOCARBINE | — | 1 | 6.00 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Ki | = | 0.337 | nM | 9.47 |
| CHEMBL71589 | PILOCARBINE | Ki | = | 1011.0 | nM | 6.00 |
| CHEMBL14 | CARBACHOL | Ki | = | 18810.0 | nM | 4.73 |