Assay Detail
Binding
CHEMBL752701
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Binding affinity against opioid receptor delta in rats by displacing [3H]DPDPE
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.40 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296603 | DELTORPHINE II | — | 1 | 9.92 |
| CHEMBL317956 | DELTORPHIN C | — | 1 | 9.62 |
| CHEMBL263670 | — | — | 1 | 9.29 |
| CHEMBL342209 | — | — | 1 | 8.80 |
| CHEMBL142547 | — | — | 1 | 8.79 |
| CHEMBL139885 | — | — | 1 | 8.62 |
| CHEMBL140384 | — | — | 1 | 7.47 |
| CHEMBL140845 | — | — | 1 | 7.32 |
| CHEMBL143208 | — | — | 1 | 7.14 |
| CHEMBL143354 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296603 | DELTORPHINE II | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL317956 | DELTORPHIN C | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL263670 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL342209 | — | Ki | = | 1.58 | nM | 8.80 |
| CHEMBL142547 | — | Ki | = | 1.62 | nM | 8.79 |
| CHEMBL139885 | — | Ki | = | 2.39 | nM | 8.62 |
| CHEMBL140384 | — | Ki | = | 33.9 | nM | 7.47 |
| CHEMBL140845 | — | Ki | = | 48.1 | nM | 7.32 |
| CHEMBL143208 | — | Ki | = | 71.8 | nM | 7.14 |
| CHEMBL143354 | — | Ki | = | 100.6 | nM | 7.00 |