Assay Detail
Binding
CHEMBL753277
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Compound was evaluated for the binding affinity towards Opioid receptor delta 1 in rat brain homogenates using [3H]naltrindole as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 14-alkoxymorphinans. 14.1 14-ethoxy-5-methyl substituted indolomorphinans with opioid receptor selectivity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.70 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 9.48 |
| CHEMBL558004 | — | — | 1 | 9.11 |
| CHEMBL608246 | — | — | 1 | 8.24 |
| CHEMBL608245 | — | — | 1 | 7.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL558004 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL608246 | — | Ki | = | 5.75 | nM | 8.24 |
| CHEMBL608245 | — | Ki | = | 10.8 | nM | 7.97 |