Assay Detail
Functional
CHEMBL753288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of the drug to inhibit wild type P388 murine leukemia cell growth in culture
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
DNA-directed alkylating agents. 6. Synthesis and antitumor activity of DNA minor groove-targeted aniline mustard analogues of pibenzimol (Hoechst 33258)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.49 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138738 | — | — | 1 | 8.00 |
| CHEMBL335278 | — | — | 1 | 7.70 |
| CHEMBL136144 | — | — | 1 | 7.22 |
| CHEMBL134422 | — | — | 1 | 6.30 |
| CHEMBL138595 | — | — | 1 | 6.10 |
| CHEMBL137445 | — | — | 1 | 6.07 |
| CHEMBL301735 | HOECHST 33258 | — | 1 | 5.92 |
| CHEMBL137443 | — | — | 1 | 5.92 |
| CHEMBL341166 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138738 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL335278 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL136144 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL134422 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL138595 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL137445 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL301735 | HOECHST 33258 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL137443 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL341166 | — | IC50 | = | 7000.0 | nM | 5.16 |