Assay Detail
Functional
CHEMBL753297
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against P388 leukemia cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.31 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347195 | — | — | 1 | 6.80 |
| CHEMBL345384 | — | — | 1 | 6.62 |
| CHEMBL345881 | — | — | 1 | 6.58 |
| CHEMBL156776 | — | — | 1 | 6.37 |
| CHEMBL347684 | — | — | 1 | 6.32 |
| CHEMBL347466 | — | — | 1 | 6.32 |
| CHEMBL156818 | — | — | 1 | 6.26 |
| CHEMBL3350557 | — | — | 1 | 6.16 |
| CHEMBL370100 | REBECCAMYCIN | — | 1 | 5.91 |
| CHEMBL154620 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347195 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL345384 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL345881 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL156776 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL347684 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL347466 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL156818 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3350557 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL370100 | REBECCAMYCIN | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL154620 | — | IC50 | = | 1940.0 | nM | 5.71 |