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Assay Detail

CHEMBL753303

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In Vitro Cytotoxicity was measured by quantifying clonogenic survival in soft agar following a 1 hr transient exposure of P388 mouse leukemia cells to compound
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type P388
Confidence 1 — Organism
Curated By Intermediate

Target

P388 (CHEMBL389)
Type CELL-LINE
Organism Mus musculus

Publication

Cyclic variations of SR 233377 (WIN 33377) and effects on antitumor activity
Wentland MP, Perni RB, Huang JI, Powles RG, Aldous SC, Klingbeil KM, Danielle Peverly A, Robinson RG, Corbett TH, Jones JL, Rake JB, Coughlin SA
Bioorg Med Chem Lett (1996) 6 : 1345 -1350
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.96 8.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL30104 1 8.36
CHEMBL27233 1 7.96
CHEMBL43 AMSACRINE 4.0 1 6.82
CHEMBL25908 1 6.82
CHEMBL283395 1 6.52
CHEMBL287205 1 6.48
CHEMBL27542 1 6.30
CHEMBL53463 DOXORUBICIN 4.0 1 6.08
CHEMBL281022 1 5.24
CHEMBL27064 1 4.89
CHEMBL30099 1 4.80
CHEMBL30053 1 4.52
CHEMBL29836 1 4.35
CHEMBL280609 1 4.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL30104 IC50 = 4.4 nM 8.36
CHEMBL27233 IC50 = 11.0 nM 7.96
CHEMBL43 AMSACRINE IC50 = 150.0 nM 6.82
CHEMBL25908 IC50 = 150.0 nM 6.82
CHEMBL283395 IC50 = 300.0 nM 6.52
CHEMBL287205 IC50 = 330.0 nM 6.48
CHEMBL27542 IC50 = 500.0 nM 6.30
CHEMBL53463 DOXORUBICIN IC50 = 830.0 nM 6.08
CHEMBL281022 IC50 = 5800.0 nM 5.24
CHEMBL27064 IC50 = 13000.0 nM 4.89
CHEMBL30099 IC50 = 16000.0 nM 4.80
CHEMBL30053 IC50 = 30000.0 nM 4.52
CHEMBL29836 IC50 = 45000.0 nM 4.35
CHEMBL280609 IC50 = 55000.0 nM 4.26