Assay Detail
Functional
CHEMBL753317
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO cells expressing Opioid receptor kappa 1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and opioid activity of side-chain-to-side-chain cyclic dynorphin A-(1-11) amide analogues cyclized between positions 2 and 5. 1. Substitutions in position 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.50 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411282 | — | — | 1 | 9.41 |
| CHEMBL439272 | — | — | 1 | 9.27 |
| CHEMBL261992 | — | — | 1 | 9.19 |
| CHEMBL414904 | — | — | 1 | 8.38 |
| CHEMBL405307 | — | — | 1 | 7.92 |
| CHEMBL438044 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411282 | — | EC50 | = | 0.39 | nM | 9.41 |
| CHEMBL439272 | — | EC50 | = | 0.54 | nM | 9.27 |
| CHEMBL261992 | — | EC50 | = | 0.65 | nM | 9.19 |
| CHEMBL414904 | — | EC50 | = | 4.19 | nM | 8.38 |
| CHEMBL405307 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL438044 | — | EC50 | = | 153.0 | nM | 6.82 |