Compound Detail
CHEMBL261992
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CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1CNC(=O)C[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL261992 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | SICMOTJZRKLQIY-KXGMHOHRSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
1388.7
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.96
EC50 1 meas. best 9.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Kappa-type opioid receptor CHEMBL3614 | EC50 | 9.19 | 9.19 | 0.7 | 1 |
| Kappa-type opioid receptor CHEMBL3614 | Ki | 8.96 | 8.96 | 1.1 | 1 |
| Mu-type opioid receptor CHEMBL270 | Ki | 8.6 | 8.6 | 2.5 | 1 |
| Delta-type opioid receptor CHEMBL3222 | Ki | 7.51 | 7.51 | 30.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Kappa-type opioid receptor | EC50 | = | 0.65 | nM | 9.19 | Inhibition of forskolin-stimulated adenylyl cyclase activity by compound in CHO ... | 14711314 |
| Kappa-type opioid receptor | Ki | = | 1.1 | nM | 8.96 | Binding affinity towards Opioid receptor kappa 1 expressed in CHO cells was dete... | 14711314 |
| Mu-type opioid receptor | Ki | = | 2.52 | nM | 8.6 | Binding affinity towards Opioid receptor mu 1 expressed in CHO cells was determi... | 14711314 |
| Delta-type opioid receptor | Ki | = | 30.8 | nM | 7.51 | Binding affinity towards opioid receptor delta 1 expressed in CHO cells was dete... | 14711314 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14711314 | 10.1021/jm030298e | Kappa-type opioid receptor | 2 |
| 14711314 | 10.1021/jm030298e | Mu-type opioid receptor | 1 |
| 14711314 | 10.1021/jm030298e | Delta-type opioid receptor | 1 |
| 14711314 | 10.1021/jm030298e | Opioid receptors; mu/kappa/delta | 1 |
Data from ChEMBL 36 via Core Engine