Assay Detail
Binding
CHEMBL757535
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Binding affinity towards opioid receptor delta 1 expressed in CHO cells was determined by using [3H]DPDPE as radioligand
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and opioid activity of side-chain-to-side-chain cyclic dynorphin A-(1-11) amide analogues cyclized between positions 2 and 5. 1. Substitutions in position 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.09 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428669 | — | — | 1 | 8.48 |
| CHEMBL438781 | — | — | 1 | 8.41 |
| CHEMBL411282 | — | — | 1 | 8.29 |
| CHEMBL415330 | — | — | 1 | 8.22 |
| CHEMBL216640 | — | — | 1 | 8.21 |
| CHEMBL414477 | — | — | 1 | 7.94 |
| CHEMBL262963 | — | — | 1 | 7.63 |
| CHEMBL261992 | — | — | 1 | 7.51 |
| CHEMBL440449 | — | — | 1 | 7.26 |
| CHEMBL439272 | — | — | 1 | 6.86 |
| CHEMBL414360 | — | — | 1 | 6.78 |
| CHEMBL415795 | — | — | 1 | 6.67 |
| CHEMBL415818 | — | — | 1 | 6.09 |
| CHEMBL405721 | — | — | 1 | 6.03 |
| CHEMBL405307 | — | — | 1 | 6.02 |
| CHEMBL410152 | — | — | 1 | 6.02 |
| CHEMBL440810 | — | — | 1 | 5.97 |
| CHEMBL414904 | — | — | 1 | 5.15 |
| CHEMBL438044 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428669 | — | Ki | = | 3.31 | nM | 8.48 |
| CHEMBL438781 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL411282 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL415330 | — | Ki | = | 6.07 | nM | 8.22 |
| CHEMBL216640 | — | Ki | = | 6.18 | nM | 8.21 |
| CHEMBL414477 | — | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL262963 | — | Ki | = | 23.3 | nM | 7.63 |
| CHEMBL261992 | — | Ki | = | 30.8 | nM | 7.51 |
| CHEMBL440449 | — | Ki | = | 55.1 | nM | 7.26 |
| CHEMBL439272 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL414360 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL415795 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL415818 | — | Ki | = | 813.0 | nM | 6.09 |
| CHEMBL405721 | — | Ki | = | 927.0 | nM | 6.03 |
| CHEMBL405307 | — | Ki | = | 949.0 | nM | 6.02 |
| CHEMBL410152 | — | Ki | = | 959.0 | nM | 6.02 |
| CHEMBL440810 | — | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL414904 | — | Ki | = | 7070.0 | nM | 5.15 |
| CHEMBL438044 | — | Ki | > | 10000.0 | nM | - |