Assay Detail
Functional
CHEMBL753334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against forskolin-stimulated cAMP production in chinese hamster ovary cells expressing Opioid receptor delta 1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Syntheses of potent Leu-enkephalin analogs possessing beta-hydroxy-alpha,alpha-disubstituted-alpha-amino acid and their characterization to opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.34 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2114469 | — | — | 1 | 11.00 |
| CHEMBL60936 | — | — | 1 | 10.15 |
| CHEMBL2114470 | — | — | 1 | 8.70 |
| CHEMBL31421 | — | — | 1 | 8.40 |
| CHEMBL2115492 | — | — | 1 | 8.00 |
| CHEMBL2373084 | — | — | 1 | 6.85 |
| CHEMBL62688 | — | — | 1 | 5.30 |
| CHEMBL2115493 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2114469 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL60936 | — | IC50 | = | 0.071 | nM | 10.15 |
| CHEMBL2114470 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL31421 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2115492 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2373084 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL62688 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2115493 | — | IC50 | = | 0.005 | nM | - |