Assay Detail
Binding
CHEMBL753340
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Inhibition of [3H]DSLET binding to rat brain membrane Opioid receptor delta 1
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.97 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15595 | — | — | 1 | 8.60 |
| CHEMBL302408 | — | — | 1 | 6.43 |
| CHEMBL303513 | — | — | 1 | 6.38 |
| CHEMBL65047 | — | — | 1 | 6.07 |
| CHEMBL68177 | — | — | 1 | 5.88 |
| CHEMBL63407 | — | — | 1 | 5.65 |
| CHEMBL66039 | — | — | 1 | 5.45 |
| CHEMBL63235 | — | — | 1 | 5.38 |
| CHEMBL303418 | — | — | 1 | 5.30 |
| CHEMBL304431 | — | — | 1 | 4.55 |
| CHEMBL63972 | — | — | 1 | - |
| CHEMBL64949 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15595 | — | Ki | = | 2.53 | nM | 8.60 |
| CHEMBL302408 | — | Ki | = | 373.0 | nM | 6.43 |
| CHEMBL303513 | — | Ki | = | 422.0 | nM | 6.38 |
| CHEMBL65047 | — | Ki | = | 849.0 | nM | 6.07 |
| CHEMBL68177 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL63407 | — | Ki | = | 2220.0 | nM | 5.65 |
| CHEMBL66039 | — | Ki | = | 3570.0 | nM | 5.45 |
| CHEMBL63235 | — | Ki | = | 4170.0 | nM | 5.38 |
| CHEMBL303418 | — | Ki | = | 5060.0 | nM | 5.30 |
| CHEMBL304431 | — | Ki | = | 28100.0 | nM | 4.55 |
| CHEMBL63972 | — | Ki | > | 380000.0 | nM | - |
| CHEMBL64949 | — | Ki | > | 60000.0 | nM | - |