Assay Detail
Binding
CHEMBL753344
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Binding affinity towards delta receptor in rat brain using [3H]DSLET
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.33 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35838 | [LEU5]ENKEPHALIN | — | 1 | 8.60 |
| CHEMBL338198 | — | — | 1 | 5.70 |
| CHEMBL126611 | — | — | 1 | 5.61 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 5.41 |
| CHEMBL126794 | — | — | 1 | - |
| CHEMBL338113 | — | — | 1 | - |
| CHEMBL338572 | — | — | 1 | - |
| CHEMBL339725 | — | — | 1 | - |
| CHEMBL129323 | — | — | 1 | - |
| CHEMBL339724 | — | — | 1 | - |
| CHEMBL2370620 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35838 | [LEU5]ENKEPHALIN | Ki | = | 2.53 | nM | 8.60 |
| CHEMBL338198 | — | Ki | = | 1980.0 | nM | 5.70 |
| CHEMBL126611 | — | Ki | = | 2450.0 | nM | 5.61 |
| CHEMBL333357 | ENDOMORPHIN 2 | Ki | = | 3940.0 | nM | 5.41 |
| CHEMBL126794 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL338113 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL338572 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL339725 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL129323 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL339724 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2370620 | — | Ki | > | 10000.0 | nM | - |