Assay Detail
Binding
CHEMBL753393
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Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.92 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27729 | — | — | 1 | 8.59 |
| CHEMBL26987 | — | — | 1 | 8.48 |
| CHEMBL283910 | — | — | 1 | 8.23 |
| CHEMBL281274 | — | — | 1 | 8.23 |
| CHEMBL283265 | — | — | 1 | 8.23 |
| CHEMBL283480 | — | — | 1 | 8.14 |
| CHEMBL418020 | — | — | 1 | 8.08 |
| CHEMBL27699 | — | — | 1 | 8.05 |
| CHEMBL447779 | — | — | 1 | 7.96 |
| CHEMBL26999 | — | — | 1 | 7.82 |
| CHEMBL283617 | — | — | 1 | 7.78 |
| CHEMBL285377 | — | — | 1 | 7.72 |
| CHEMBL28172 | — | — | 1 | 7.58 |
| CHEMBL280827 | — | — | 1 | 7.50 |
| CHEMBL26483 | — | — | 1 | 7.21 |
| CHEMBL27093 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27729 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL26987 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL283910 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL281274 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL283265 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL283480 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL418020 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL27699 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL447779 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL26999 | — | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL283617 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL285377 | — | Ki | = | 19.2 | nM | 7.72 |
| CHEMBL28172 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL280827 | — | Ki | = | 31.7 | nM | 7.50 |
| CHEMBL26483 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL27093 | — | Ki | = | 77.0 | nM | 7.11 |