Assay Detail
Binding
CHEMBL753434
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Inhibition of [3H]DPDPE binding to Opioid receptor delta 1
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.84 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296603 | DELTORPHINE II | — | 1 | 9.39 |
| CHEMBL282873 | — | — | 1 | 9.27 |
| CHEMBL21177 | — | — | 1 | 9.02 |
| CHEMBL278289 | — | — | 1 | 8.48 |
| CHEMBL279132 | — | — | 1 | 8.02 |
| CHEMBL277862 | — | — | 1 | 7.90 |
| CHEMBL20422 | — | — | 1 | 7.86 |
| CHEMBL435762 | — | — | 1 | 7.59 |
| CHEMBL283763 | — | — | 1 | 7.23 |
| CHEMBL281845 | — | — | 1 | 6.92 |
| CHEMBL280669 | — | — | 1 | 6.32 |
| CHEMBL21192 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296603 | DELTORPHINE II | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL282873 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL21177 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL278289 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL279132 | — | Ki | = | 9.46 | nM | 8.02 |
| CHEMBL277862 | — | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL20422 | — | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL435762 | — | Ki | = | 25.8 | nM | 7.59 |
| CHEMBL283763 | — | Ki | = | 58.5 | nM | 7.23 |
| CHEMBL281845 | — | Ki | = | 120.4 | nM | 6.92 |
| CHEMBL280669 | — | Ki | = | 476.5 | nM | 6.32 |
| CHEMBL21192 | — | Ki | = | 741.5 | nM | 6.13 |