Assay Detail
Binding
CHEMBL753672
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Binding affinity towards Opioid receptor delta 1 using [3H]DADLE as radioligand.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.70 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38685 | — | — | 1 | 7.11 |
| CHEMBL2373184 | — | — | 1 | 7.08 |
| CHEMBL2373217 | — | — | 1 | 6.99 |
| CHEMBL544473 | — | — | 1 | 6.83 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.17 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 5.99 |
| CHEMBL2373216 | — | — | 1 | - |
| CHEMBL2373185 | — | — | 1 | - |
| CHEMBL290411 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38685 | — | Ki | = | 77.3 | nM | 7.11 |
| CHEMBL2373184 | — | Ki | = | 84.06 | nM | 7.08 |
| CHEMBL2373217 | — | Ki | = | 103.42 | nM | 6.99 |
| CHEMBL544473 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL70 | MORPHINE | Ki | = | 684.0 | nM | 6.17 |
| CHEMBL596 | FENTANYL | Ki | = | 1035.0 | nM | 5.99 |
| CHEMBL2373216 | — | Ki | > | 3.0 | nM | - |
| CHEMBL2373185 | — | Ki | > | 1.5 | nM | - |
| CHEMBL290411 | — | Ki | > | 1.0 | nM | - |