Assay Detail
Binding
CHEMBL753813
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In vitro inhibitory activity was determined against Opioid receptor mu 1 in guinea pig ileum
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Enkephalin analogues with 2',6'-dimethylphenylalanine replacing phenylalanine in position 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.76 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100480 | — | — | 1 | 9.26 |
| CHEMBL109327 | — | — | 1 | 8.70 |
| CHEMBL8234 | ENKEPHALIN | — | 1 | 6.99 |
| CHEMBL109554 | — | — | 1 | 6.09 |
| CHEMBL112708 | — | — | 1 | - |
| CHEMBL111028 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100480 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL109327 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL8234 | ENKEPHALIN | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL109554 | — | IC50 | = | 808.0 | nM | 6.09 |
| CHEMBL112708 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL111028 | — | IC50 | > | 10.0 | nM | - |