Assay Detail
Binding
CHEMBL754207
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Binding affinity to Opioid receptor mu 1 in rat brain using [3H]-NAL as radioligand
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and analgesic properties of N-substituted trans-4a-aryldecahydroisoquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.25 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359363 | — | — | 1 | 9.64 |
| CHEMBL155216 | — | — | 2 | 9.02 |
| CHEMBL56585 | CYCLAZOCINE | 2.0 | 1 | 8.92 |
| CHEMBL153538 | — | — | 1 | 8.38 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.24 |
| CHEMBL415284 | NALORPHINE | 2.0 | 1 | 8.19 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 8.16 |
| CHEMBL150667 | — | — | 1 | 7.54 |
| CHEMBL153661 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359363 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL155216 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL56585 | CYCLAZOCINE | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL153538 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL70 | MORPHINE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL415284 | NALORPHINE | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL155216 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL150667 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL153661 | — | Ki | = | 473.0 | nM | 6.33 |