Compound Detail
CHEMBL359363
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Basic Information
| ChEMBL ID | CHEMBL359363 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RZQYAGNFCZDLPG-BBQAJUCSSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
335.5
MW (Da)
4.77
ALogP
2
HBA
1
HBD
23.5
PSA (Ų)
0.87
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mu-type opioid receptor CHEMBL270 | Ki | 9.64 | 9.64 | 0.2 | 1 |
| Kappa-type opioid receptor CHEMBL3952 | Ki | 7.05 | 7.05 | 89.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | Ki | = | 0.23 | nM | 9.64 | Binding affinity to Opioid receptor mu 1 in rat brain using [3H]-NAL as radiolig... | 2831363 |
| Kappa-type opioid receptor | Ki | = | 89.0 | nM | 7.05 | Binding affinity to Opioid receptor kappa 1 in guinea pig cortex using [3H]EKC a... | 2831363 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2831363 | 10.1021/jm00398a011 | Mu-type opioid receptor | 3 |
| 2831363 | 10.1021/jm00398a011 | Kappa-type opioid receptor | 3 |
| 2831363 | 10.1021/jm00398a011 | Mus musculus | 1 |
| 2831363 | 10.1021/jm00398a011 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine