Assay Detail
Binding
CHEMBL754624
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Binding affinity to Opioid receptor kappa 1 in guinea pig cortex using [3H]EKC as radioligand
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and analgesic properties of N-substituted trans-4a-aryldecahydroisoquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.35 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | 2.0 | 1 | 8.89 |
| CHEMBL153538 | — | — | 1 | 8.60 |
| CHEMBL415284 | NALORPHINE | 2.0 | 1 | 7.82 |
| CHEMBL155216 | — | — | 2 | 7.21 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 7.12 |
| CHEMBL359363 | — | — | 1 | 7.05 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.78 |
| CHEMBL150667 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL153538 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL415284 | NALORPHINE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL155216 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL359363 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL70 | MORPHINE | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL155216 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL150667 | — | Ki | = | 529.0 | nM | 6.28 |