Assay Detail
Binding
CHEMBL754284
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Binding affinity for Opioid receptor delta 1 by the inhibition of binding of [3H]DADAL in rat brain membranes.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.71 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431276 | — | — | 1 | 8.38 |
| CHEMBL316845 | — | — | 1 | 8.32 |
| CHEMBL102150 | — | — | 1 | 8.18 |
| CHEMBL98800 | — | — | 1 | 8.15 |
| CHEMBL101316 | — | — | 1 | 7.88 |
| CHEMBL101231 | — | — | 1 | 7.74 |
| CHEMBL330644 | — | — | 1 | 7.46 |
| CHEMBL98644 | — | — | 1 | 6.75 |
| CHEMBL319790 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431276 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL316845 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL102150 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL98800 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL101316 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL101231 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL330644 | — | IC50 | = | 34.5 | nM | 7.46 |
| CHEMBL98644 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL319790 | — | IC50 | = | 281.0 | nM | 6.55 |