Assay Detail
Binding
CHEMBL754468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.66 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153648 | — | — | 1 | 9.30 |
| CHEMBL150609 | — | — | 1 | 8.83 |
| CHEMBL13470 | SNC-80 | — | 1 | 8.40 |
| CHEMBL338980 | — | — | 1 | 8.31 |
| CHEMBL542267 | — | — | 1 | 8.30 |
| CHEMBL544641 | — | — | 1 | 7.98 |
| CHEMBL545335 | — | — | 1 | 7.92 |
| CHEMBL544638 | — | — | 1 | 7.70 |
| CHEMBL346625 | — | — | 1 | 7.57 |
| CHEMBL555570 | — | — | 1 | 7.57 |
| CHEMBL555571 | — | — | 1 | 7.37 |
| CHEMBL150430 | — | — | 1 | 7.36 |
| CHEMBL552849 | — | — | 1 | 6.61 |
| CHEMBL150785 | — | — | 1 | 6.59 |
| CHEMBL541349 | — | — | 1 | 6.48 |
| CHEMBL153183 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153648 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL150609 | — | Ki | = | 1.48 | nM | 8.83 |
| CHEMBL13470 | SNC-80 | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL338980 | — | Ki | = | 4.85 | nM | 8.31 |
| CHEMBL542267 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL544641 | — | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL545335 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL544638 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL346625 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL555570 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL555571 | — | Ki | = | 43.2 | nM | 7.37 |
| CHEMBL150430 | — | Ki | = | 44.2 | nM | 7.36 |
| CHEMBL552849 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL150785 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL541349 | — | Ki | = | 328.0 | nM | 6.48 |
| CHEMBL153183 | — | Ki | = | 622.0 | nM | 6.21 |