Assay Detail
Binding
CHEMBL754474
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Inhibition of binding of [3H]-DPDPE to opioid receptor delta 1 from rat brain membrane.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Piperazinyl benzamidines: synthesis and affinity for the delta opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.00 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301516 | — | — | 1 | 8.91 |
| CHEMBL13470 | SNC-80 | — | 1 | 8.77 |
| CHEMBL297498 | — | — | 1 | 7.93 |
| CHEMBL49463 | — | — | 1 | 7.80 |
| CHEMBL48983 | — | — | 1 | 7.69 |
| CHEMBL47001 | — | — | 1 | 7.64 |
| CHEMBL49347 | — | — | 1 | 7.53 |
| CHEMBL297574 | — | — | 1 | 7.27 |
| CHEMBL300057 | — | — | 1 | 7.24 |
| CHEMBL49712 | — | — | 1 | 7.23 |
| CHEMBL48542 | — | — | 1 | 7.20 |
| CHEMBL51539 | — | — | 1 | 7.06 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.05 |
| CHEMBL46031 | — | — | 1 | 7.04 |
| CHEMBL48417 | — | — | 1 | 7.02 |
| CHEMBL295618 | — | — | 1 | 7.00 |
| CHEMBL48590 | — | — | 1 | 6.93 |
| CHEMBL48785 | — | — | 1 | 6.85 |
| CHEMBL51473 | — | — | 1 | 6.80 |
| CHEMBL49874 | — | — | 1 | 6.77 |
| CHEMBL48476 | — | — | 1 | 6.75 |
| CHEMBL49144 | — | — | 1 | 6.67 |
| CHEMBL301587 | — | — | 1 | 6.65 |
| CHEMBL49660 | — | — | 1 | 6.56 |
| CHEMBL48932 | — | — | 1 | 6.54 |
| CHEMBL50657 | — | — | 1 | 6.39 |
| CHEMBL49741 | — | — | 1 | 6.26 |
| CHEMBL48852 | — | — | 1 | 6.26 |
| CHEMBL48325 | — | — | 1 | 6.12 |
| CHEMBL45877 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301516 | — | Ki | = | 1.22 | nM | 8.91 |
| CHEMBL13470 | SNC-80 | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL297498 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL49463 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL48983 | — | Ki | = | 20.5 | nM | 7.69 |
| CHEMBL47001 | — | Ki | = | 22.9 | nM | 7.64 |
| CHEMBL49347 | — | Ki | = | 29.6 | nM | 7.53 |
| CHEMBL297574 | — | Ki | = | 53.5 | nM | 7.27 |
| CHEMBL300057 | — | Ki | = | 57.6 | nM | 7.24 |
| CHEMBL49712 | — | Ki | = | 58.5 | nM | 7.23 |
| CHEMBL48542 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL51539 | — | Ki | = | 87.3 | nM | 7.06 |
| CHEMBL70 | MORPHINE | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL46031 | — | Ki | = | 91.1 | nM | 7.04 |
| CHEMBL48417 | — | Ki | = | 95.3 | nM | 7.02 |
| CHEMBL295618 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL48590 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL48785 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL51473 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL49874 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL48476 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL49144 | — | Ki | = | 212.0 | nM | 6.67 |
| CHEMBL301587 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL49660 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL48932 | — | Ki | = | 292.0 | nM | 6.54 |
| CHEMBL50657 | — | Ki | = | 405.0 | nM | 6.39 |
| CHEMBL49741 | — | Ki | = | 543.0 | nM | 6.26 |
| CHEMBL48852 | — | Ki | = | 545.0 | nM | 6.26 |
| CHEMBL48325 | — | Ki | = | 764.0 | nM | 6.12 |
| CHEMBL45877 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL298343 | — | Ki | = | 859.0 | nM | 6.07 |
| CHEMBL48883 | — | Ki | = | 1023.0 | nM | 5.99 |