Assay Detail
Binding
CHEMBL754476
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Inhibition of radioligand [3H]DADLE binding to rat brain delta receptor
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A marked change of receptor affinity of the 2-methyl-5-(3-hydroxyphenyl)morphans upon attachment of an (E)-8-benzylidene moiety: synthesis and evaluation of a new class of sigma receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.39 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38791 | — | — | 2 | 6.92 |
| CHEMBL322468 | — | — | 1 | 6.62 |
| CHEMBL2008608 | — | — | 1 | 6.57 |
| CHEMBL2111686 | — | — | 1 | 6.30 |
| CHEMBL3350264 | — | — | 1 | 6.13 |
| CHEMBL2111684 | — | — | 1 | 5.70 |
| CHEMBL110319 | — | — | 1 | - |
| CHEMBL109160 | — | — | 1 | - |
| CHEMBL2111685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38791 | — | Ki | = | 121.5 | nM | 6.92 |
| CHEMBL322468 | — | Ki | = | 240.4 | nM | 6.62 |
| CHEMBL2008608 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL38791 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL2111686 | — | Ki | = | 504.9 | nM | 6.30 |
| CHEMBL3350264 | — | Ki | = | 734.7 | nM | 6.13 |
| CHEMBL2111684 | — | Ki | = | 1989.0 | nM | 5.70 |
| CHEMBL110319 | — | Ki | > | 500.0 | nM | - |
| CHEMBL109160 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2111685 | — | Ki | > | 500.0 | nM | - |