Assay Detail
Binding
CHEMBL754480
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Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.84 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311995 | NALTREXONEDIAZONIUM | — | 1 | 9.22 |
| CHEMBL314209 | — | — | 1 | 9.15 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 8.17 |
| CHEMBL312281 | — | — | 1 | 7.12 |
| CHEMBL312046 | — | — | 1 | 7.00 |
| CHEMBL310829 | — | — | 1 | 6.40 |
| CHEMBL81328 | — | — | 1 | - |
| CHEMBL309542 | — | — | 1 | - |
| CHEMBL312040 | ETONITAZENE | 2.0 | 1 | - |
| CHEMBL81465 | — | — | 1 | - |
| CHEMBL84237 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311995 | NALTREXONEDIAZONIUM | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL314209 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL19019 | NALTREXONE | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL312281 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL312046 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL310829 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL81328 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL309542 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL312040 | ETONITAZENE | Ki | > | 1000.0 | nM | - |
| CHEMBL81465 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL84237 | — | Ki | > | 1000.0 | nM | - |