Assay Detail
Binding
CHEMBL754481
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Opioid receptor delta 1 binding affinity by displacement of radioligand [3H][D-Pen]-enkephalin (DPDPE) from rat brain membrane synaptosomes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.99 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | — | 1 | 9.82 |
| CHEMBL1790779 | — | — | 1 | 8.89 |
| CHEMBL2370328 | — | — | 1 | 8.81 |
| CHEMBL1790778 | — | — | 1 | 7.17 |
| CHEMBL278789 | DERMORPHIN | — | 1 | 7.08 |
| CHEMBL2369626 | — | — | 1 | 7.06 |
| CHEMBL2370329 | — | — | 1 | 5.75 |
| CHEMBL2370331 | — | — | 1 | 5.68 |
| CHEMBL2370332 | — | — | 1 | 5.02 |
| CHEMBL2370333 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL1790779 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2370328 | — | Ki | = | 1.55 | nM | 8.81 |
| CHEMBL1790778 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL278789 | DERMORPHIN | Ki | = | 82.5 | nM | 7.08 |
| CHEMBL2369626 | — | Ki | = | 86.8 | nM | 7.06 |
| CHEMBL2370329 | — | Ki | = | 1760.0 | nM | 5.75 |
| CHEMBL2370331 | — | Ki | = | 2110.0 | nM | 5.68 |
| CHEMBL2370332 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL2370333 | — | Ki | = | 22600.0 | nM | 4.65 |