Assay Detail
Binding
CHEMBL754484
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Inhibition of [3H]DTLET binding torat brain membrane Opioid receptor delta 1
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.84 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55734 | — | — | 1 | 8.87 |
| CHEMBL57776 | — | — | 1 | 8.83 |
| CHEMBL55498 | — | — | 1 | 8.51 |
| CHEMBL56933 | — | — | 1 | 8.33 |
| CHEMBL124283 | — | — | 1 | 8.32 |
| CHEMBL298972 | — | — | 1 | 8.21 |
| CHEMBL299029 | — | — | 1 | 8.20 |
| CHEMBL13786 | — | — | 1 | 8.14 |
| CHEMBL31421 | — | — | 1 | 7.96 |
| CHEMBL301702 | — | — | 1 | 7.72 |
| CHEMBL56394 | — | — | 1 | 6.06 |
| CHEMBL299497 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55734 | — | Ki | = | 1.35 | nM | 8.87 |
| CHEMBL57776 | — | Ki | = | 1.47 | nM | 8.83 |
| CHEMBL55498 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL56933 | — | Ki | = | 4.68 | nM | 8.33 |
| CHEMBL124283 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL298972 | — | Ki | = | 6.14 | nM | 8.21 |
| CHEMBL299029 | — | Ki | = | 6.35 | nM | 8.20 |
| CHEMBL13786 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL31421 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL301702 | — | Ki | = | 19.2 | nM | 7.72 |
| CHEMBL56394 | — | Ki | = | 866.0 | nM | 6.06 |
| CHEMBL299497 | — | Ki | = | 13000.0 | nM | 4.89 |