Assay Detail
Binding
CHEMBL754564
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Inhibitory activity was determined in stimulating [35S]-GTP-gamma S binding mediated by the Opioid receptor mu 1 in chinese Hamster Ovary (CHO)membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.27 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | — | 1 | 8.77 |
| CHEMBL413512 | — | — | 1 | 8.74 |
| CHEMBL147511 | — | — | 1 | 7.80 |
| CHEMBL405131 | — | — | 1 | 7.05 |
| CHEMBL358104 | — | — | 1 | 7.05 |
| CHEMBL424328 | — | — | 1 | 7.00 |
| CHEMBL357334 | — | — | 1 | 6.89 |
| CHEMBL433697 | — | — | 1 | 6.77 |
| CHEMBL346436 | — | — | 1 | 6.44 |
| CHEMBL146756 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL413512 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL147511 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL405131 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL358104 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL424328 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL357334 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL433697 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL346436 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL146756 | — | IC50 | = | 610.0 | nM | 6.21 |