Assay Detail
Binding
CHEMBL754594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition against binding of radioligand [leucyl-3H]-OFQ to membrane of human embryonic kidney 293 cells overexpressing rat Opioid receptor like 1
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.42 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166387 | — | — | 1 | 10.10 |
| CHEMBL354291 | — | — | 1 | 10.09 |
| CHEMBL440928 | — | — | 1 | 9.62 |
| CHEMBL355202 | — | — | 1 | 9.39 |
| CHEMBL354545 | — | — | 1 | 9.31 |
| CHEMBL354652 | — | — | 1 | 9.02 |
| CHEMBL354065 | — | — | 1 | 8.82 |
| CHEMBL353990 | — | — | 1 | 8.72 |
| CHEMBL166445 | — | — | 1 | 8.70 |
| CHEMBL436243 | — | — | 1 | 8.48 |
| CHEMBL168578 | — | — | 1 | 8.34 |
| CHEMBL165885 | — | — | 1 | 8.33 |
| CHEMBL169947 | — | — | 1 | 8.15 |
| CHEMBL354163 | — | — | 1 | 7.92 |
| CHEMBL263575 | — | — | 1 | 7.60 |
| CHEMBL352490 | — | — | 1 | 7.39 |
| CHEMBL353608 | — | — | 1 | 7.28 |
| CHEMBL168513 | — | — | 1 | 6.50 |
| CHEMBL170674 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166387 | — | Ki | = | 0.079 | nM | 10.10 |
| CHEMBL354291 | — | Ki | = | 0.082 | nM | 10.09 |
| CHEMBL440928 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL355202 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL354545 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL354652 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL354065 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL353990 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL166445 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL436243 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL168578 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL165885 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL169947 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL354163 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL263575 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL352490 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL353608 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL168513 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL170674 | — | Ki | = | 600.0 | nM | 6.22 |