Compound Detail
CHEMBL166387
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Basic Information
| ChEMBL ID | CHEMBL166387 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AYIPPDCLGFAXBJ-KDURUIRLSA-N |
4
Targets
5
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
355.5
MW (Da)
3.63
ALogP
3
HBA
1
HBD
35.6
PSA (Ų)
0.90
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 10.1
EC50 1 meas. best 7.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nociceptin receptor CHEMBL4503 | Ki | 10.1 | 10.1 | 0.1 | 1 |
| Mu-type opioid receptor CHEMBL270 | Ki | 8.49 | 8.49 | 3.2 | 1 |
| Kappa-type opioid receptor CHEMBL3614 | Ki | 7.58 | 7.58 | 26.0 | 1 |
| Nociceptin receptor CHEMBL4503 | EC50 | 7.42 | 7.42 | 38.0 | 1 |
| Delta-type opioid receptor CHEMBL269 | Ki | 6.62 | 6.62 | 242.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nociceptin receptor | Ki | = | 0.079 | nM | 10.1 | Inhibition against binding of radioligand [leucyl-3H]-OFQ to membrane of human e... | 10782696 |
| Mu-type opioid receptor | Ki | = | 3.2 | nM | 8.49 | Inhibition against binding of radioligand [N-allyl-2-3-3H]-naloxone to membrane ... | 10782696 |
| Kappa-type opioid receptor | Ki | = | 26.0 | nM | 7.58 | Inhibition against binding of radioligand [N-allyl-2-3-3H]-naloxone to membrane ... | 10782696 |
| Nociceptin receptor | EC50 | = | 38.02 | nM | 7.42 | pEC50 for its effect on stimulating GTPgammaS binding to membranes of HEK 293 ce... | 10782696 |
| Delta-type opioid receptor | Ki | = | 242.0 | nM | 6.62 | Inhibition against binding of radioligand [Ile5,6-3H]-deltorphin to membrane fro... | 10782696 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10782696 | 10.1016/s0960-894x(00)00111-6 | Nociceptin receptor | 2 |
| 10782696 | 10.1016/s0960-894x(00)00111-6 | Unchecked | 2 |
| 10782696 | 10.1016/s0960-894x(00)00111-6 | Mu-type opioid receptor | 1 |
| 10782696 | 10.1016/s0960-894x(00)00111-6 | Kappa-type opioid receptor | 1 |
| 10782696 | 10.1016/s0960-894x(00)00111-6 | Delta-type opioid receptor | 1 |
Data from ChEMBL 36 via Core Engine