Assay Detail
Binding
CHEMBL753282
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Inhibition against binding of radioligand [Ile5,6-3H]-deltorphin to membrane from baby hamster kidney cells infected with forest virus encoding the cDNAs for rat Opioid receptor delta 1
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
ORL1 receptor ligands: structure-activity relationships of 8-cycloalkyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.08 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433720 | — | — | 1 | 9.72 |
| CHEMBL354545 | — | — | 1 | 7.82 |
| CHEMBL354291 | — | — | 1 | 7.34 |
| CHEMBL355202 | — | — | 1 | 7.00 |
| CHEMBL166387 | — | — | 1 | 6.62 |
| CHEMBL354065 | — | — | 1 | 6.48 |
| CHEMBL436243 | — | — | 1 | 6.35 |
| CHEMBL354652 | — | — | 1 | 6.24 |
| CHEMBL168578 | — | — | 1 | 6.17 |
| CHEMBL353990 | — | — | 1 | - |
| CHEMBL169947 | — | — | 1 | - |
| CHEMBL166445 | — | — | 1 | - |
| CHEMBL440928 | — | — | 1 | - |
| CHEMBL165885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433720 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL354545 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL354291 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL355202 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL166387 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL354065 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL436243 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL354652 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL168578 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL353990 | — | Ki | > | 200.0 | nM | - |
| CHEMBL169947 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL166445 | — | Ki | > | 540.0 | nM | - |
| CHEMBL440928 | — | Ki | > | 200.0 | nM | - |
| CHEMBL165885 | — | Ki | > | 2000.0 | nM | - |